Sleep apnea endotypes and phenotypes: Use of new technology in obstructive sleep apnea
Atul Malhotra, MD
Chief of Pulmonary, Critical Care and Sleep Medicine | Kenneth M. Moser Professor
Director of Sleep Medicine, UC San Diego Health System (United States)
Keynote Summary: Obstructive sleep apnea(OSA) afflicts up to 1 billion people worldwide. OSA treatment is clearly beneficial yet limited by variable efficacy and/or incomplete adherence to therapy. We have used a mechanistic approach to understand the endotypes underlying OSA with a view towards personalizing treatment based on individual characteristics. Using microRNAs, plasma exosomes, metabolomics and microbiome assessment, we are working to understand basic mechanisms underlying disease to identify which patients are at risk of particular complications, allowing more sophisticated trial designs in the future. We are further using Big Data to assess real world patient outcomes and to implement new technologies to optimize adherence with existing technologies.
Biosketch: Dr. Malhotra is Chief of Pulmonary, Critical Care and Sleep Medicine at UCSD. After 17 years at Harvard, he arrived in San Diego in 2013 as the Kenneth M. Moser Professor of Medicine at UCSD. He is a past President of the American Thoracic Society (2015-2016), which is the world’s leading professional society in pulmonary, critical care and sleep medicine. Dr. Malhotra has over 500 publications (250 original) since coming on faculty in 2000. His research foci include sleep apnea pathogenesis, cardiometabolic complications of sleep disorders and applied physiology of mechanical ventilation. He is a world leader in the area of sleep apnea and lectures internationally on this topic.