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Courses

Courses will be offered the Friday, Saturday and Sunday preceding World Sleep 2022. Course titles, speakers and details are subject to change.

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World Sleep 2022 Pre-Congress Courses

Friday Courses | 10:00am – 2:00pm

Course Chairs
Sonia Ancoli-Israel (United States)
Meir Kryger (United States)

Summary
For centuries, artists have explored the meaning of sleep in mythology, religion, dreams, healing and death. This special course will focus on how sleep and sleep medicine have intersected with the arts, literature and the Bible.

In the evening, participants will be given a private, small group tour of one of the museums in Rome, with a focus on paintings and sculptures depicting sleep.

Note: The museum tour is optional and an additional ticket will need to be purchased to attend the tour. Only course registrants may attend the tour. Spouses may also purchase a tour ticket.

Learning Objectives
Upon completion of this CME activity, participants should be able to:

  1. Recognize how sleep has been depicted in the visual arts
  2. Discuss how sleep is depicted in sacred literature
  3. Recognize the intersection of sound and sleep
  4. Identify representations of narcolepsy in popular media and be prepared to discuss with patients how the representations may differ from first-hand patient experience

Schedule

Introduction | 10:00am – 10:10am
Sonia Ancoli-Israel (United States)
Maier Kryger (United States)

Sleep in art and literature | 10:10am – 10:55am
Meir Kryger (United States)

Sleep in the bible | 10:55am – 11:40am
Sonia Ancoli-Israel (United States)

Coffee break | 11:40am – 12:00pm

Narcolepsy in cinema | 12:00pm – 12:45pm
Julie Flygare (United States)

Sleep in sound | 12:45pm – 1:30pm
Milton Mermikides (United Kingdom)
Debra Skene (United Kingdom)

Open discussion / Q&A | 1:30pm – 2:00pm

 

Saturday Full-Day Courses | 8:00am – 5:00pm

Course Chairs
Patrick Strollo (United States)
Atul Malhotra (United States)

Summary
Obstructive Sleep Apnea (OSA) is a common clinical problem that has a substantial impact on quality of life, daytime performance and is associated with an increased risk of cardiometabolic disease. This postgraduate course will focus on how precision medicine can be leveraged in the diagnosis and management of OSA. Evidence based approaches will be discussed. Current controversies as well as future strategies will be presented by the international faculty.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Review sleep apnea pathogenesis emphasizing individual variability
  2. Recognize the global burden of sleep apnea
  3. Consider therapeutic strategies for OSA at present and in the future

 

Schedule

8:00am–8:10 am
Introduction

8:10am–8:30am
Beyond the AHI: Revisiting metrics of SDB

8:30am–8:50am
Newer OSA metrics

8:50am–9:15am
OSA endotypes/Pathogenesis of OSA

9:15am–9:40am
Targeting endotypes/Phenotypes clinically

9:40am–10:00am
Coffee break

10:00am–10:20am
PAP therapy

10:20am–10:45am
PAP outcomes

10:45am–11:05am
Oral appliance update

11:05am–11:30am
Big data

11:30am–12:00pm
Open panel discussion / Q&A

12:00pm–1:00pm
Lunch break

1:00pm–1:20pm
UA surgery update medical

1:20pm–1:45pm
UA surgical

1:45pm–2:05pm
Alternatives / Complimentary Rx – UA Muscle

2:05pm–2:30pm
OSA pharmacology

2:30pm–2:50pm
Coffee break

2:50pm–3:05pm
Successfully managing co-morbid disease: Insomnia and COPD

3:05pm–3:20pm
OSA and heart disease

3:20pm–3:35pm
OSA and elderly

3:35pm–3:55pm
OSA care transformed by COVID

3:55pm–4:15pm
OSA outcome measures

4:15pm–5:00pm
Conclusion/Q&A/Open panel discussion

Course Chairs
Sabra Abbott (United States)
Till Roenneberg (Germany)

Summary
Circadian disruption is associated with, and possibly contributes to numerous diseases and disorders affecting nearly all systems of the body. The overall theme of this course is to provide a larger view of circadian rhythm disorders as more than a subtype of "sleep disorders” but highlight their bi-directional relationship with systemic disorders. This course will cover an update on the neural and systemic biology of circadian rhythms, challenges in clinical diagnosis and management, focusing on new data. The intent is to move away from circadian disorders as “sleep disorders’ but more as systemic disorders. This is the first step for sleep medicine physicians taking ownership of circadian medicine.

Learning objectives

Upon completion of this CME activity, participants will be able to:

  1. Identify that healthy clocks give more trouble than broken clocks
  2. Recognize that diagnostic interpretations are much stronger if associated with circadian analyses
  3. Expand the definition of circadian rhythm disorders beyond that of just a sleep-wake problem
  4. Understand that sleep is more than lying down and closing your eyes

Schedule

8:00am – 08:10am
Introduction 
Sabra Abbott (United States)
Till Roenneberg (Germany)

8:10am – 08:55am
Neurobiology of circadian rhythms
William Schwartz (United States)

8:55am – 09:40am
The role of a healthy circadian clock in disease: The circadian clinic model |
Till Roenneberg (Germany)
Sabra Abbott (United States)

9:40am – 10:00am
Coffee break 

10:00am – 10:45am
Genetics, rest activity patterns and autism
Maja Bucan (United States)

10:45am – 11:30am
Circadian dysfunction in neurodegenerative disorders
Speaker to be announced.

11:30am – 12:00pm
Open discussion / Q&A
Sabra Abbott (United States)
Till Roenneberg (Germany)

12:00pm – 1:00pm
Lunch break

1:00pm – 1:45pm
Circadian rhythms in depression
Sean Cain (Australia)

1:45pm – 2:30pm
Impact of circadian rhythms on cardiovascular disease and recovery
Tami Martino (Canada)

2:30pm – 2:50pm
Coffee break

2:50pm – 3:35pm
Circadian rhythms in the hospital setting
Matthew Maas (United States)

3:35pm – 4:20pm
The impacts of Daylight Savings Time on health and disease
Elizabeth Klerman (United States)

4:20pm – 5:00pm
Conclusion/Q&A/Open discussion
Sabra Abbott (United States)
Till Roenneberg (Germany)

Course Chairs
Fernanda Almeida (Canada)
Maria Clotilde Carra (France)

Summary
Obstructive sleep apnea (OSA) is a major health problem affecting nearly 1 billion of adults aged 30–69 years worldwide. Undiagnosed and untreated OSA is associated to severe health consequences and an important economic burden, with billions of dollars lost each year due to loss in working days and productivity, as well as increase in healthcare expenses.

Dental professionals can have a primary role in the screening and treatment of OSA. This course is designed to bring up-to-date and exciting information for new and experienced clinicians and researchers in the field of Dental Sleep Medicine. Specifically, it will focus on clinical and imaging tools to screen OSA, indications and outcomes of oral appliance therapy, and principles and strategies to manage OSA comorbidities, such as sleep bruxism, orofacial pain, headache, and periodontal diseases.

This is a clinically-focused and evidence-based continuing education program combining worldwide experts to bring to attendees the newest knowledge and its application to clinical practice.

Learning objectives
Upon completion of this CME activity, participants should be able to:.

  1. Screen OSA with clinical and imaging tools in adult and pediatric populations
  2. Gain understanding of oral appliance therapy, indications, efficacy and treatment protocols
  3. Recognize the importance of OSA patient’s follow-up and management of treatment side effects
  4. Identify OSA comorbidities and interactions with other diseases pertinent to dental professionals
  5. Promote a multidisciplinary approach, which includes dentistry, in sleep medicine

Schedule

8:00am–8:10am
Introduction

8:10 am–8:40 am
Understanding the physiology of the upper airway collapse

8:40 am–9:10 am
Can we use imaging or other tools to screen OSA?

9:10 am–9:40 am
Decision criteria for the selection of OSA treatment and what is available for dentists

9:40 am–10:00 am
Coffee break

10:00 am–10:30 am
Improving oral appliance outcomes

10:30 am–11:00 am
Long-term benefits and consequences of oral appliances

11:00 am–11:30 am
Clinical and imaging evaluation of the pediatric patients

11:30 am–12:00pm
Discussion panel with all speakers

12:00 pm–1:00 pm
Lunch

1:00pm–1:10pm
Introduction

1:10pm–1:40pm
Cardiovascular and metabolic consequences of OSA, how can the dentist help?

1:40pm–2:10pm
Interactions and treatment implications of OSA and periodontal diseases

2:10pm–2:40pm
Bruxism as a comorbidity: impact from diagnosis to treatment

2:40pm–3:00pm
Coffee break

3:00pm–3:30pm
Dealing with orofacial pain and headaches in a dental sleep medicine practice

3:30pm–4:00 pm
Is the pediatric patient this complex?

4:00pm–4:30pm
Promoting a multidisciplinary team, getting out of your comfort zone

4:30pm–5:00pm
Discussion about complex cases

Course chairs
Lourdes DelRosso (United States)
Jodi Mindell (United States)
Gustavo Moreira (Brazil)

Summary
The understanding and recognition of pediatric sleep disorders and their consequences in children has grown exponentially in the last years. This course will provide an overview and up-to-date information on the most current consensus and recommendations on diagnosis and treatment of pediatric sleep disorders. The first half of the day will focus on understanding sleep disorder breathing, insomnia and circadian rhythm disorders. The second half of the day will concentrate on movement disorders parasomnias and the practice of pediatric sleep medicine around the world. Experienced clinicians will share their knowledge with the audience and will be available for questions and discussion at the end of the morning and afternoon sessions.

Learning objectives
Upon completion of this CME activity, participants will be able to:

  1. Review the most common sleep disorders in children
  2. Identify the current consensus diagnosis updates in pediatric sleep medicine
  3. Understand the treatment options for sleep disorders and the populations at risk

Schedule

Schedule forthcoming.

 

Saturday Morning Courses | 8:00am – 12:00pm

Course chairs
Yue Leng (China)
Katie Stone (United States)

Summary
Epidemiology helps us understand the risks associated with sleep problems. This course will review what we have learned about sleep disorders from the major epidemiological studies as well as explaining the methodology behind epidemiology.

Learning objectives
Upon completion of this CME activity, participants will be able to:

  1. Understand the principles of the design and interpretation of epidemiological studies
  2. Illustrate specific methodological considerations in sleep epidemiology
  3. Discuss approaches to measuring sleep in epidemiologic studies
  4. Review evidence about sleep disorders learned from major epidemiological studies
  5. Discuss special topics in sleep epidemiology

Schedule

8:00am – 8:05am
Introduction
Yue Leng (China)
Katie Stone (United States)

8:05am – 08:45am
Assessment of sleep in cohort studies 
Katie Stone (United States)

8:45am – 9:25am
Introduction for epidemiology: Study design, confounding, bias
Yue Leng (China)

9:25am – 9:45am
Coffee break

9:45am – 10:30am
Search for causality in epidemiology: The case of sleep 
Francesco Cappuccio (United Kingdom)

10:30am – 11:15am
"Sleep health" and machine learning approaches 
Meredith Wallace (United States)

11:15am – 12:00pm
Genetics of sleep
Richa Saxena (United States)

Course chairs
Mauro Manconi (Switzerland)
John Winkelman (United States)

Summary
This course will start with a detailed review of guideline-based treatments of RLS and of dopaminergic augmentation, and then specifically discuss opioid treatment of severe, refractory RLS. Following a short break, there will be separate talks on emerging medications, and then neuromodulation treatments, for RLS, followed by a discussion of treatment of RLS in special conditions (eg renal failure, depression, sleep apnea). The final section of the course will be an interactive case discussion in which a series of difficult cases are presented with interactive involvement with the audience using online real-time participation.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Decide on when and how to start a conventional treatment in patients with RLS
  2. Recognize how to prevent and manage augmentation
  3. Evaluate indications for opioids and to reduce the risk of their abuse/misuse
  4. Discuss recent and future therapeutic approaches to RLS therapy
  5. Manage difficult, comorbid, and refractory RLS cases

Schedule

8:00am –8:10am
Introduction
Mauro Manconi (Switzerland)
John Winkelman (United States)

8:10am – 08:50am
Revision of standard guideline 
Michael Silber (United States)

8:50am – 9:20am
Augmentation

9:20am – 09:50am
Opioids
John Winkelman (United States)

9:50am – 10:00am
Coffee break 

10:00am – 10:20am
New drugs
Diego Garcia-Borreguero (Spain)

10:20am – 10:40am
Neuromodulation
Mauro Manconi (Switzerland)

10:40am – 11:10am
RLS in special conditions
Lynn Marie Trotti (United States)

11:10am – 12:00pm
Interactive cases discussion 
Mauro Manconi (Switzerland)
Lynn Marie Trotti (United States)
John Winkelman (United States)

Course Chairs
Stephany Fulda (Switzerland)
Ambra Stefani (Austria)

Summary
Visual sleep staging and scoring according to international criteria is the current gold standard. However, there is some inter-rater variability, intrinsic to the subjectivity of visual methods. This might be overcome with new technologies allowing automatic sleep staging and scoring. In this course, current standard methods for sleep staging, scoring of leg movements and scoring of REM sleep without atonia and others will be presented, and possible future changes based on new techniques e.g. artificial intelligence will be introduced.

Learning objectives
Learning objectives forthcoming.

Schedule

8:00am–8:10am
Introduction
Stephany Fulda (Switzerland)
Ambra Stefani (Austria)

8:10 am–8:55am
Sleep scoring: What can we do better?

8:55am–09:25am
Leg movement scoring: What do you need to know?
Stephany Fulda (Switzerland)

9:25am–9:55am
How to deal with REM sleep without atonia and video analysis for RBD diagnosis
Ambra Stefani (Austria)

9:55am–10:10am
Coffee break

10:10am–10:55am
Digital sleep: Novel PSG metrics

10:55am–11:40am
AI to advance sleep scoring: How to understand it?
Matteo Cesari (Austria)

11:40am–12:00pm
Q&A / Open discussion
Stephany Fulda (Switzerland)
Ambra Stefani (Austria)

 

Saturday Afternoon Courses | 1:00pm – 5:00pm

Course chairs
Chandra Jackson (United States)
Girardin Jean-Louis (United States)

Summary
During this half-day course, we will define and describe sleep health disparities across the globe, describe the multi-level, multi-factorial determinants of sleep health disparities across the globe, and identify potential interventions to promote sleep health equity as well as research challenges and opportunities to address global sleep health disparities.

Learning objectives
Upon completion of this CME activity, participants will be able to:

  1. Define and describe sleep health disparities across the globe
  2. Describe the multi-level, multi-factorial determinants of sleep health disparities across the globe
  3. Identify potential interventions as well as research challenges and opportunities to address sleep health disparities across the globe

Schedule

1:00pm – 1:10pm
Introduction
Chandra Jackson (United States)
Girardin Jean-Louis (United States)

1:10pm – 1:55pm
Introduction to the multi-level determinants of sleep health disparities
Chandra Jackson (United States)

1:55pm – 2:40pm
Physical environments and sleep health disparities across the globe

2:40pm – 3:00pm
Coffee break

3:00pm – 3:45pm
Social environment and sleep health disparities across the globe

3:45pm – 4:30pm
Potential interventions 

4:30pm – 5:00pm
Conclusion/Q&A/Open discussion 

Course chairs
Max Hirshkowitz (United States)
Massimiliano de Zambotti (United States)

Summary
Consumer Sleep Technology (CST) application for both for sleep research and sleep medicine continues to grow. This course will review CST’s role in sleep science and clinical practice. Limitation, advantages, and practical guidelines will be discussed, with particular emphasis on CST performance. We will also describe CST use for measuring sleep-relevant physiology (e.g., heart rate variability, cardiopulmonary coupling), beyond classical sleep indices.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Understand the use and limits of polysomnographic, actigraphic, and consumer wearable multi-sensor sleep assessment.
  2. Understand concepts and differences underlying performance evaluation vs. validation.
  3. Understand role and capability of CST in clinical and research settings for tracking sleep and related physiology.

Schedule

1:00pm – 1:10pm
Introduction
Massimiliano de Zambotti (United States)
Max Hirshkowitz (United States)

1:10pm – 1 :55pm
How do we measure sleep? When a standard is the gold standard?
Max Hirshkowitz (United States)

1:55pm – 2:40pm
Beyond motion: The nature and rational behind multi-sensor CST, and CST performance evaluation process
Luca Menghini (Italy)

2:40pm – 3:00pm
Coffee break

3:00pm – 3:45pm
CST landscape and performance in measuring sleep, Evaluation of Pros and Cons of CST and practical points
Massimiliano de Zambotti (United States)

3:45pm – 4:30pm
Not only sleep tracking: Application of CSTs for measuring sleep-related physiology
Thomas Penzel

4:30pm – 5:00pm
Open discussion / Q&A

Course chairs
Federica Provini (Italy)
Carlos Schenck (United States)

Summary
Clinical and video-polysomnographic knowledge on the parasomnias and sleep related seizures keeps advancing, including diagnostic features and therapies, with enhanced patient care and deepened scientific knowledge. This course will encompass NREM parasomnias (Disorders of Arousal and Sleep Related Eating Disorder), Sleep related seizures, Dreaming and dream disorders across NREM and REM sleep, causes of sleep violence, and update on RBD and Parasomnia Overlap Disorder. Management challenges will be identified and discussed.

Schedule

1:00pm – 1:10pm
Introduction
Federica Provini (Italy)
Carlos Schenck (United States)

1:10pm – 1:55pm
DOA across the lifespan and how to distinguish from nocturnal seizures
Federica Provini (Italy)

1:55pm – 2:40pm
Sleep related eating disorder and its differential diagnosis
Yuichi Inoue (Japan)

2:40pm – 3:00pm
Coffee break

3:00pm – 3:45pm
Dreaming and dream disorders across NREM and REM sleep
Isabelle Arnulf (United States)

3:45pm – 4:30pm
Causes of sleep violence and update on RBD and parasomnia overlap disorder
Carlos Schenck (United States)

4:30pm – 5:00pm
Summary of key points and Q & A
Federica Provini (Italy)
Carlos Schenck (United States)

 

Sunday Full-Day Courses | 8:00am – 5:00pm

Course Chairs
Winfried Randerath (Germany)
Dieter Riemann (Germany)

Summary
This course will bring together recent findings on basic science and clinical advances from several fields of sleep research and sleep medicine. The course puts together the best science of the year for certain topics. The focus will be on areas where there has been substantial progress in the past few years. Speakers will provide up-to-date and evidence based information to the clinical management of patients with a variety of sleep disorders. To achieve the best .selection of science for this course, two experienced researchers from sleep research and sleep medicine, Dieter Riemann and Winfried Randerath, will chair the course. Dieter Riemann is editor of the Journal of Sleep Research for over than five years now and just recently he was awarded the PISA Sleep Award. Winfried Randerath is a well known expert in the field of sleep-related breathing disorders and editor of the Journal Sleep Medicine.

Learning objectives
Upon completion of this CME activity, participants will be able to:

  1. Recognize the relationships between sleep, insomnia and emotion regulation
  2. Discuss the many different aspects of sleep in women
  3. Identify the mechanisms of insomnia and its major treatments
  4. Recognize the relationships between sleep and mental disorders, sleep-related breathing disorders, epilepsy and narcolepsy

Schedule

8:00am – 08:05am
Introduction
Dieter Riemann (Germany)

8:05am – 08:50am
Sleep and emotion regulation
Chiara Baglioni (Germany)

8:50am – 09:35am
Narcolepsy
Yves Dauvilliers (France)

9:35am – 09:55am
Coffee break

9:55am – 10:40am
Insomnia mechanisms
Kai Spiegelhalder (Germany)

10:40am – 11:25am
Cognitive behavioral therapeutics for insomnia
Colin Espie (United Kingdom)

11:25am – 12:10pm
Novel psychotherapeutic approaches for insomnia
Elisabeth Hertenstein (Switzerland)

12:10pm – 1:10pm
Lunch break

1:10pm – 1:55pm
Sleep and psychiatry
Christoph Nissen (Switzerland)

1:55pm – 2:40pm
Sleep-related breathing disorders
Winfried Randerath (Germany)

2:40pm – 3:00pm
Coffee break

3:00pm – 3:45pm
Sleep and epilepsy
Birgit Frauscher (Canada)

3:45pm – 4:30pm
Women's sleep
Laura Palagini (Italy)

4:30pm – 5:00pm
Open discussion / Q&A

Course Chairs
Maree Barnes (Australia)
Sara Nowakowski (United States)

Summary
Women have a different experience of sleep and sleep disorders compared to men. This may be related to hormonal influences, anatomical and physiological reasons and social and environmental factors. These may all influence disease presentation, natural course, and the response to, choice and use of therapies. This course will discuss normal sleep and sleep disorders in females throughout the lifespan and at different stages of life.

We will begin by looking at normal sleep through the lifespan, from childhood, through adolescence and menarche, during child-bearing years and pregnancy, then into menopause and older age. Several speakers will focus on the treatment of insomnia with CBTi for women and pregancy-related sleep disorders, particularly sleep-disordered breathing and leg movement disorders. We will discuss the challenges of modern life as it specifically effects women’s sleep.

Learning objectives

Upon completion of this CME activity, participants should be able to:

  1. Recognize how sleep in women differs from sleep in men, at all stages of life
  2. Assess the impact that hormonal changes in women have on sleep, particularly during menarche, the menstrual cycle, pregnancy and menopause.
  3. Recognize the sleep disorders that specifically accompany pregnancy and impact maternal and feotal well-being.
  4. Identify circadian misalignment as it pertains to women in particular.

Schedule

8:00am – 8:10am
Welcome
Sara Nowakowski (United States)

8:10am – 8:55am
Adolescent sex differences
Mary Carskadon (United States)

8:55am – 9:40am
The relationship between the menstrual cycle and sleep
Fiona Baker (United States)

9:40am – 10:25am
Upper airway physiology, females and males
Danny Eckert (Australia)

10:25am – 10:45am
Coffee break

10:45am – 11:30am
Normal sleep and CBT-i in pregnancy
Lianne Tomfohr-Madesen (Canada)

11:30am – 12:15pm
SDB in Pregnancy
Danielle Wilson (Australia)

12:15pm – 12:30pm
Open discussion
Danielle Wilson (Australia)

12:30pm – 1:15pm
Lunch break

1:15pm – 2:00pm
Women, circadian rhythms and shift work
Diane Boivin (Canada)

2:00pm – 2:45pm
Sleep and mental health in women
Laura Palagini (Italy)

2:45pm – 3:00pm
Coffee break

3:00pm – 3:45pm
The impact of menopause on sleep

3:45pm – 4:30pm
Sleep in the post-menopausal woman
Helena Hachul (Brazil)

4:30pm – 5:00pm
Open discussion
Sara Nowakowski (United States)
Maree Barnes (Australia)

Course chairs
Claudio Liguori (Italy)
Aleksandar Videnovic (United States)

Summary
It is increasingly recognized that sleep and sleep disorders are often present and a significant part of the neurodegenerative diseases (NDDs), which are more common among the elderly. Moreover, detecting and treating sleep disorders in these populations have a considerable interest as a potential way to impact the development and the course of NDDs. The course will give an overview from the sleep changes associated with the process of aging to the sleep abnormalities associated with different NDDs (i.e. Alzheimer disease, Parkinson disease, Lewy body dementia). This course aims to increase participants' knowledge and skills on the impact on sleep and sleep disorders in subjects with neurodegenerative diseases, and the effect of neurodegenerative disease on sleep.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Recognize the impact of aging on sleep and circadian rhythms
  2. Discuss sleep disturbances associated with most common neurodegenerative disorder
  3. Recognize the role of the circadian system in neurodegenerative disorders
  4. Discuss the bi-directional relationship between sleep/wake homeostasis and neurodegeneration

Schedule

8:00 – 08:10am
Introduction
Claudio Liguori (Italy)
Aleksandar Videnovic (United States)

8:10am – 09:03am
Sleep and circadian rhythms in healthy aging
Donald Bilwise (United States)

9:03am – 09:56am
Sleep disordered breathing and neurodegeneration 
Claudio Liguori (Italy)

9:56 – 10:16
Coffee break

10:16am – 11:09am
Sleep dysfunction in movement disorders
Claudia Trenkwalder (Germany)

11:09am – 12:02pm
Circadian biology of movement disorders
Aleksandar Videnovic (United States)

12:02pm – 1:02pm
Lunch break

1:02pm – 1:55pm
Sleep, clocks, and alzheimer’s disease
Bryce Mander (United States)

1:55pm – 2:48pm
What animal models teach us about sleep and neurodegeneration 
Oliver Rawashdeh (Australia)

2:48pm – 3:08pm
Coffee break

3:08pm – 4:01pm
REM sleep behavior disorder: A disorder on the intersection of neurology, neuroscience and sleep medicine
Ambra Stefani (Austria)

4:01pm – 5:00pm
Case studies of sleep and circadian disorders associated with neurodegeneration
Claudio Liguori (Italy)
Aleksandar Videnovic (United States)
Bryce Mander (United States)
Oliver Rawashdeh (Australia)
Ambra Stefani (Austria)
Claudia Trenkwalder (Germany)

Course Chairs
Luciano Drager (Brazil)
Virend Somers (United States)

Summary
Summary forthcoming.

Learning objectives
Learning objectives forthcoming.

Schedule

8:00am – 08:10am
Welcome and introduction
Luciano Drager (Brazil)
Virend Somers (United States)

8:10am – 08:55am
OSA and CV disease: Significant findings and emerging questions from the last 3 years
Ferran Barbe (Spain)

8:55am – 9:40am
OSA beyond adults! What we have learned from the cardiovascular impact of OSA in Children?
Raouf Amin (United States)

9:40am – 10:00am
Coffee break

10:00am – 10:45am
OSA and hypertension: Is the game over or are there new paths to follow?
Martino Pengo (Italy)

10:45am – 11:30am
The impact of OSA on metabolic syndrome and diabetes: Myth or reality?
Luciano Drager (Brazil)

11:30am – 12:00pm
Open discussion / Q&A

12:00pm – 1:00pm
Lunch break

1:00pm – 1:45pm
It’s not just the AHI: Sleepiness as a risk factor in OSA 
Naima Covassin (United States)

1:45pm – 2:30pm
It’s not just the AHI: The impact of hypoxemic burden on CV events
Ali Azarbazin (United States)

2:30pm – 2:50pm
Coffee break 

2:50pm – 3:35pm
Why haven’t treatment trials in OSA shown cardiovascular benefits?
Shahrokh Javaheri (United States)

3:35pm – 4:20pm
Cardiovascular RCTs in OSA: What is new?
Doug Bradley (Canada)

Conclusion/Q&A/Open discussion | 4:20pm – 5:00pm

 

Sunday Morning Courses | 8:00am – 12:00pm

Course Chairs
Josee Savard (Canada)
Lisa Wu (Denmark)

Summary
Cancer and its treatment is associated with a range of co-occurring symptoms such as fatigue and sleep disturbance both before, during and even years after the end of cancer treatment. Circadian rhythm changes are also often observed among cancer patients, and may play an important role in the fatigue and sleep disturbance that cancer patients experience. This course will examine these relationships as well as potential treatments to ameliorate fatigue and sleep disturbance in cancer patients with a focus on two primary interventions – light therapy and cognitive behavioral therapy for insomnia – that have been used in cancer patients with sleep and fatigue problems. We will also actively engage participants in small group activities and discussions regarding how to apply and adapt interventions to cancer populations using case studies for inspiration.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Describe sleep, fatigue and circadian rhythm disruption in cancer patients.
  2. Describe how circadian disruption may drive sleep and fatigue symptoms in cancer patients.
  3. Identify different approaches to treat insomnia and circadian rhythm disruption in cancer patients.

Schedule

08:00am – 08:10am
Introduction
Josee Savard (Canada)
Lisa Wu (Denmark)

8:10am – 08:45am
Introduction to sleep, fatigue and circadian rhythms in cancer
Sonia Ancoli-Israel (United States)

8:45am – 09:20am
Systematic light exposure for the treatment of sleep disturbance and fatigue in cancer 
Lisa Wu (Denmark)

9:20am – 09:40am
Coffee break

9:40am – 10:15am
Internet-delivered cognitive-behavioral therapy for insomnia in breast cancer survivors
Ali Amidi (Denmark)

10:15am – 10:50am
The implementation of cognitive behavioral therapy for insomnia in routine cancer care
Josee Savard (Canada)

10:50am – 11:25am
Implementation and adaptation to cancer populations: Case study activity 
Josee Savard (Canada)
Lisa Wu (Denmark)
Ali Amidi (Denmark)
Sonia Ancoli-Israel (United States)

11:25am – 12:00pm
Live discussion / Q&A 
Josee Savard (Canada)
Lisa Wu (Denmark)

Course Chairs
David Neubauer (United States)
Gary Zammit (United States)

Summary
The use of medications in the treatment of insomnia remains an important therapeutic option. As more compounds and formulations have become available there now are greater opportunities for personalizing care for patients based on their symptoms and circumstances, as well as medication pharmacologic properties. This course will review the key features of approved insomnia disorder medications, including benzodiazepine receptor agonists, melatonin receptor agonists, histamine receptor antagonists, and orexin receptor antagonists. Investigational compounds, commonly prescribed “off-label” medications, over-the-counter products, and dietary supplements also will be discussed. Special attention will be given to issues related to medication abuse potential, effects on daytime functioning, and improvements in quality of life. The course will conclude with a comprehensive review of clinical trials for insomnia medications that will include protocol designs, objective and subjective efficacy measures, and adverse reaction assessments.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Compare and contrast medications indicated for the treatment of insomnia disorder
  2. Discuss key factors that contribute to personalized care in the pharmacologic management of insomnia
  3. Recognize the potential abuse liability associated with insomnia medications
  4. Explain fundamental design elements in clinical trials for insomnia medications

Schedule
Schedule forthcoming.

Course Chairs
Dan Buysse (United States)
Bjørn Bjorvatn (Norway)

Summary
Good sleep promotes health and function, and poor sleep increases risk for disease and poor function. But what exactly constitutes “good sleep”? How can we measure it? What health outcomes is it related to? And how can we treat poor sleep to make it better? These are the questions addressed in this course. Two orthogonal perspectives are useful in considering sleep and health relationships. The first perspective relies on the identification of discrete sleep disorders. The second perspective—the multidimensional sleep health (MDSH) perspective—recognizes that even in the absence of sleep disorders, an individual’s sleep is characterized by multiple features (e.g., duration, timing, efficiency). These features, individually and in aggregate, also affect health. This course will include five talks addressing practical aspects of MDSH: The first talk will consider the concept of sleep health and its potential utility for understanding sleep-health relationships (Buysse). The second talk will discuss the validation and use of self-report measures for MDSH including questionnaires and sleep diaries (Coelho/de Batlle). The third talk will discuss objective measures of MDSH, including actigraphy and PSG (Brindle?). The fourth talk will focus on measurement issues, including the identification of informative clusters of MDSH profiles (Wallace). The fifth and final talk will discuss behavioral interventions drawing on the MDSH construct (Harvey).

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Describe the concept of multidimensional sleep health
  2. Utilize self-report and objective measures of multidimensional sleep health
  3. Employ behavioral techniques to improve multidimensional sleep health

Schedule
Schedule forthcoming.

 

Sunday Afternoon Courses | 1:00pm – 5:00pm

Course Chairs
Isaac Almendros (Spain)
David Gozal (United States)

Summary
This course will review the biological and epidemiological evidence linking sleep disorders in general, and more specifically sleep apnea with cancer. The impact of sleep disruption and deprivation as well as shifts in circadian homeostatic processes can elicit activation of selective cellular pathways that ultimately may result in increased propensity for malignant transformation (oncogenesis) and foster cellular proliferation and aggressiveness while deregulating immunosurveillance . Intermittent hypoxia as occurs in sleep apnea and many other respiratory and cardiovascular conditions can also elicit unique molecular signaling processes that while distinct from those related to sleep perturbation have the ability to induce activation and propagation of oncocellular mechanisms. Furthermore, resistance to therapeutic interventions may also develop under such conditions. However, the epidemiological data are conflictive and may be providing cues that merit more structured and better deigned research studies. These issues will be addressed in the course.

Learning objectives
Learning objectives forthcoming.

Schedule

1:00pm – 1:15pm
Introduction
David Gozal (United States)
Isaac Almendros (Spain)

1:15pm – 2:05pm
Circadian and sleep aspects of cancer
Maria Paola Mogavero (Italy)

2:05pm – 2:25pm
Coffee break

2:25pm – 3:15pm
Intermittent hypoxia and cancer: Lessons from cellular and animal models
Isaac Almendros (Spain)

3:15pm – 4:05pm
Sleep apnea and cancer: Scandalous bedtime stories
David Gozal (United States)

4:05pm – 5:00pm
Open discussion and Q&A

Course chairs
Colleen Carney (Canada)
Jason Ellis (United Kingdom)

Summary
Worldwide, Cognitive Behavioral Therapy for Insomnia (CBT-I) is considered the first line management strategy for Insomnia Disorder. That said, knowledge of, and access to, CBT-I remains a challenge. The overall aim of this session will be to provide a state of the art understanding of CBT-I both in terms of research and clinical practice. Starting with an overview of CBT-I, the audience will be introduced to CBT-I, its structure, components and delivery. Following, the impact from recent research in the area of CBT-I will be discussed with particular reference to adjuvant therapies, identifying non-treatment responders and addressing socio-economic barriers to treatment. The second half of the course takes us into the clinical arena where a case formulation approach to Insomnia Disorder in the context of CBT-I will be outlined. Finally, new innovations in the clinical practice of behavioral treatments for Insomnia Disorder will be explored, which aim to address the existing challnges around treatment in the 'real world’, including the management of insomnia co-morbid with other sleep disorders.

Learning objectives
Upon completion of this CME activity, participants should be able to:

  1. Discuss the components of CBT-I and their relative importance to managing Insomnia Disorder
  2. Describe recent advances in CBT-I research, ranging from adjuvent therapies, to managing acute insomnia in the context of COVID-19
  3. Discuss how a case formulation for Insomnia Disorder is made with reference to CBT-I
  4. Describe recent advances in the clinical practice of CBT-I

Schedule

1:00pm – 1:10pm
Introduction
Colleen Carney (Canada)
Jason Ellis (United Kingdom)

1:10pm – 1:55pm
Overview of CBT-I
Ellemarije Altena (France)

1:55pm – 2:40pm
Innovations in CBT-I Research
Jason Ellis (united Kingdom)

2:40pm – 3:00pm
Coffee break

3:00pm – 3:45pm
Case Formulation Approach to CBT-I 
Colleen Carney (Canada)

3:45pm – 4:30pm
Innovations in CBT-I practice
Leon Lack (Australia)

4:30pm – 5:00pm
Panel discussion
Colleen Carney (Canada)
Jason Ellis (United Kingdom)

Course chairs
Yves Dauvilliers (France)
Fabio Pizza (Italy)

Summary
Summary forthcoming.

Learning objectives
Learning objectives forthcoming.

Schedule
Schedule forthcoming.

Course chairs
Chiara Baglioni (Germany)
Ruth Benca (United States)

Summary

Sleep is a fundamental operating state of the central nervous system, occupying up to a third of the human life span. As such, it may be one of the most important psychophysiological processes for brain function and mental health. Decades of research have shown that sleep disturbances are highly prevalent in mental disorders and have been associated with adverse effects for cognitive, emotional, and interpersonal functioning. While traditional models proposed that distinct sleep alterations would map to specific mental disorders, newer models emphasize the transdiagnostical nature of sleep disturbances as a dimension for brain and mental health. Epidemiological studies have pointed out that difficulties in sleep continuity may represent an important risk factor for many common mental disorders both in adult and pediatric populations. Circadian dysfunction has been also related to increased vulnerability for psychopathology. Nevertheless, classical medical approaches tend to consider sleep alterations as secondary symptoms of mental disorders. As a consequence, sleep problems are often underdiagnosed and undertreated. Their clinical consideration, instead, has been linked to better short and long-term outcomes.

 

Schedule

 

1:00pm–1:10pm
Introduction
Chiara Baglioni (Germany)
Ruth Benca (United States)

1:10pm–1:55pm
Sleep continuity as a predictor of mental disorders in adults
Chiara Baglioni (Germany)

1:55pm–2:40pm
Circadian rhythm disruption in mental disorders
Katharina Wulff (Sweden)

2:40pm–3:00pm
Coffee break

3:00pm–3:45pm
Sleep disruption in childhood and adolescence and its relationship with affective disturbances
Candice A. Alfano (United States)

3:45pm–4:30pm
Sleep EEG in insomnia and mental disorders and the effects of sleep treatment on outcomes
Ruth Benca (United States)

4:30pm–5:00pm
Conclusion/Q&A/Open discussion
Chiara Baglioni (Germany)
Ruth Benca (United States)